Efficacy of mitomycin c in endoscopic dacryocystorhinostomy

Authors

  • Vinod Shinde Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India
  • Anju Unnikrishnan Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India
  • Shad Fatma Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India
  • James Thomas Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20184355

Keywords:

Chronic dacryocystitis, Nasolacrimal duct obstruction, Dacryocystorhinostomy, Endoscopic endonasal dacryocystorhinostomy, Mitomycin C

Abstract

Background: Endoscopic dacryocystorhinostomy is a procedure done to drain the lacrimal sac due to post saccular lacrimal obstruction. The most common cause of failure of dacryocystorhinostomy is blockage of ostium created in lacrimal sac. Various methods are employed to prevent the blockage such as stenting, mitomycin C and steroidal nasal sprays. In this study we evaluated the efficacy of mitomycin C in reducing the stomal closure following dacryocystorhinostomy.

Methods: Fifty patients who were diagnosed with chronic dacryocystitis due to nasolacrimal duct obstruction were chosen for the study. They were randomly divided in to two groups. In group I 25 patients under went endoscopic dacryocystorhinostomy with intraoperative mitomycin C application and in group II 25 patients underwent endoscopic dacryocystorhinostomy without application of mitomycin C. Patients were followed up at the end of one week, three weeks, three months and six months. Surgical success was evaluated objectively at the end of six months.  

Results: The success rate of endoscopic dacryocystorhinostomy with use of mitomycin c was 86% in group where mitomycin c was used and 62% in group where mitomycin c was not used.

Conclusions: Mitomycin C is a safe drug which can keep the stoma created patent and reduces the chance of recurrence following endoscopic dacryocystorhinostomy.

Author Biographies

Vinod Shinde, Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India

Associate Professor

Department of ENT

Dr. D.Y.Patil Medical college, Pune

Anju Unnikrishnan, Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India

Senior Resident

Department of ENT

Dr. D.Y.Patil Medical college, Pune

Shad Fatma, Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India

Junior Resident

Department of ENT

Dr. D.Y.Patil Medical college, Pune

 

 

James Thomas, Department of ENT, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India

Professor and HOD

Department of ENT

Dr. D.Y.Patil Medical college, Pune

 

 

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Published

2018-10-24

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Original Research Articles