Etiology of obstructive sleep apnoea syndrome

Authors

  • Sandesh Priyadarshan Department of ENT, K S Hegde Charitable Hospital, Mangalore, Karnataka http://orcid.org/0000-0001-9013-6363
  • Shrinath D. Kamath P. Department of ENT, K S Hegde Charitable Hospital, Mangalore, Karnataka

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20174313

Keywords:

Etiology, OSA, Obstructive sleep apnoea

Abstract

Background: The aims of the study were to evaluate the various etiological factors of obstructive sleep apnoea syndrome and to make recommendations based on study findings.

Methods: The study group consists of 60 patients who are diagnosed clinically and polysomnographically to have obstructive sleep apnoea syndrome at ENT and Pulmonary Medicine outpatient departments.  

Results: Most cases of severe OSA were in age group of 21-40 (47.8%). No significant association was observed between age distribution and severity of OSA (p=0.295). A significant association was observed between obesity and increasing severity of OSA (p<0.05). The mean AHI of patients with mild, moderate and severe OSA was 8.45, 23.31 and 49.07 respectively (p<0.05). Enlarged adenoids, narrow oropharyngeal inlet, bulky tongue, enlarged tonsils and greater neck circumference were significantly associated with OSA (p<0.05). No significant association between DNS, ITH, concha bullosa and enlarged adenoids with OSA (p>0.05).

Conclusions: Certain naso-oro-pharyngeal parameters were found to be significantly associated with obstructive sleep apnoea syndrome viz. enlarged adenoids, bulky tongue, greater neck circumference and narrow oropharyngeal inlet. Patients with these features should further be investigated with CPAP titration polysomnography and surgical intervention. 

Author Biography

Sandesh Priyadarshan, Department of ENT, K S Hegde Charitable Hospital, Mangalore, Karnataka

Department of ENT, junior resident

References

Mendelson WB : Sleep related breathing disorders. In: Human sleep, research and clinical care. Newyork: Plenum Medical book company, 1985; 183-219.

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurence of sleep-disordered breathing among middle aged adults. N Engl J Med 1993;328:1230-5.

Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, et al. The influence of aging on pharyngeal collapsibility during sleep. Chest. 2007;131:1702–9.

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middleaged adults. N Engl J Med. 1993;328:1230-5.

Jordan AS, McEvoy RD. Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms. Sleep Med Rev. 2003;7:377-89.

Kaul S, Meena AK, Murthy JM. Sleep apneas syndromes: clinical and polysomnographic study Neurol India. 2001;49:47-50.

Cassel W, Canisius S, Becker HF, Leistner S, Ploch T, Jerrentrup A, et al. A prospective polysomnographic study on the evolution of complex sleep apnoea. Eur Respir J. 2011;38:329-37.

Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, VelaBueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001;163:608-13.

Knorst MM, Souza FJ, Martinez D. Obstructive sleep apnea-hypopnea syndrome: association with gender, obesity and sleepiness-related factors. J Bras Pneumol. 2008;34(7):490-6.

Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003;13:676-83.

Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med. 2003;168(5):522-30.

Zwillich CW, Pierson DJ, Hofeldt FD, Lufkin EG, Weil JV. Ventilatory control in myxedema and hypothyroidism. N Engl J Med. 1975;292:662–5.

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Published

2017-09-22

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Original Research Articles