Laryngeal cancer: a clinicopathological study of 65 cases

Authors

  • Jitendra Pratap Singh Chauhan Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
  • Bhartendu Bharti Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
  • Sunil Singh Bhadouriya Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
  • Abhay Kumar Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
  • Prem Narain Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
  • Jaypal Singh Department of ENT, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20175619

Keywords:

Larynx, Laryngeal carcinoma, Histopathological, Clinicopathological, Squamous cell carcinoma

Abstract

Background: The larynx serves protective, respiratory and phonatory functions in humans. Cancer of the larynx is common cancer of head and neck region. This study was done to determine the predisposing factors, clinical aspects and histopathological pattern of the laryngeal malignancies. Patients were studied with particular significance given to the mode of presentation, risk factors, topography and histopathology of the tumour.

Methods: This prospective study was conducted at Department of Otorhinolaryngology Head and Neck Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah. All 65 cases of laryngeal cancer presented from July 2016 to July 2017were included in this study.  

Results: Most of cases belonged to age group 51-60 years. Tobacco intake in the form of smoking was the major risk factor and present in 80% of cases. Commonest presenting symptom was the dysphagia followed by hoarseness of voice. Supraglottic area was the commonest site (69.23%) for laryngeal cancer in this study. Squamous cell carcinoma was found in 98.46% of patients. Moderately differentiated category seen in 49.23% of patients. Most of the patients presented in the stage III and IV (30.77% and 44.62%). 37 (56.92%) cases out of 65 cases had cervical lymph node metastasis at the time of presentation.

Conclusions:Diagnosis is based on proper history, clinical examination, direct visualization of the larynx, CT scan and established by histopathological examination. This study has been done to improve comprehension and care of patients with laryngeal carcinoma.

 

References

Iovanescu GH, Poenaru M, Doros C, Boruga O. Histopathological prognostic and risk factors in patients with laryngeal neoplasm. Rom J Morphol Embryol. 2013;54(4):1087-92.

Swift AC. Acute infections of larynx. In: Glesson M editor. Scott – Brown’s Otorhinolaryngology Head and Neck Surgery. 7th ed. London (GB): 2008: 2248-2257.

Parkin DM, Boyd L, Walker LC. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Summary and conclusions. Br J Cancer. 2011;105(2):77-S81.

Wyss A, Hashibe M, Chuang SC. Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Am J Epidemiol. 2013;178(5):679-90.

Islami F, Tramacere I, Rota M. Alcohol drinking and laryngeal cancer: overall and dose-risk relation--a systematic review and meta-analysis. Oral Oncology. 2010;46(11):802-10.

Chen M, Tse LA. Laryngeal cancer and silica dust exposure: a systematic review and meta-analysis, Am J Industrial Med. 2012;55(8):669-76.

Brown T, Darnton A, Fortunato L. Occupational cancer in Britain. Respiratory cancer sites: larynx, lung and mesothelioma. Br J Cancer. 2012;107(1):56-70.

Paget-Bailly S, Cyr D, Luce D. Occupational exposures and cancer of the larynx-systematic review and meta-analysis. J Occupational Environl Med. 2012;54(1):71-84.

Zhang D, Zhou J, Chen B. Gastroesophageal reflux and carcinoma of larynx or pharynx: a meta-analysis. Acta Otolaryngologica. 2014;134(10):982-9.

Li X, Gao L, Li H. Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis. J Infect Dis. 2013;207(3):479-88.

Mendenhall WM, Werning JW, Pfister DG. Treatment of head and neck cancer. In: DeVita VT Jr, Lawrence TS, Rosenberg SA: Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2011:729-780.

Sharma DK, Sohhal BS, Bal MS, Agrawal S. Clinicopathological study of 50 cases of tumours of larynx. Indian J Otolaryngol Head Neck Surg. 2013;65:29-35.

Parsad KC, Abraham P, Peter R. Malignancy of the larynx in a child. ENT Ear Nose Throat J. 2001;80(8):508-11.

Saedi B, Razmpa E, Sadeghi M, Mojtahed M, Mojtahed A. The epidemiology of laryngeal cancer in a country on the esophageal cancer belt. Indian J of Otolaryngol Head Neck Surg. 2009;61(3):213-7.

Lam KY, Yuen AP. Cancer of the larynx in Hong Kong: a clinico-pathological study. Eur J Surg Oncol. 1996;22(2):166-70.

Bakshi J, Panda NK, Sharma S, Gupta AK, Mann SBS. Survival pattern in treated cases of carcinoma larynx in north India: a 10 year follow up study. Ind J Otolaryngology Head Neck Surg. 2004;56(2):99-103.

Goito MC, Fernandes AUR. Risk factors of laryngeal cancer in patients attended in the oral oncology centre of Aracatuba. Braz J Oral Sci. 2005;4(13):741-44.

Almadori G, Bussu F, Gadoni G, Galli J, Paludetti G, Maurizi M. Molecular markers in laryngeal Squamous cell carcinoma: Towards an integrated clinicobiological approach. Eur J Cancer. 2005;41:683-93.

Maier H, Gewelke U, Dietz A, Heller W. Risk factors ofcancer of the larynx: results of the Heidelberg case–control study. Otolaryngol Head Neck Surg. 1992;107(4):577–82.

Thekdi AA, Ferris RL. Diagnostic assessment of laryngeal cancer. Otolaryngologic Clinics of North Am. 2002;35:953-69.

Yerma A, Mehta S, Panda NK. Presentation of carcinoma larynx and laryngopharynx an analysis of 840 cases. Indian J Otolaryngol. 1990;42:50-3.

Deka RC, Kacker SK. Glandular theory of cancer spread in the larynx. Indian J Otolaryngol. 1976;28:115.

Datti PV, Patel CB, Sayed BA. The incidence of laryngeal cancer in Baroda. Indian J Otolaryngology. 1971;23:152-62.

Matsuo JM, Patel SG, Singh B, Wong RJ, Boyle JO, Kraus DH. Clinical nodal stage is an independently significant predictor of distant failure in patients with squamous cell carcinoma of the larynx. Annals Surgical Oncol. 2003;238(3):412-22.

Wang M, Liu C, Li W, Chang S, Chu P. Salivary glandcarcinoma of the larynx. J Chin Med Assoc. 2006;69(7):322–5.

Suen JY, Stern SJ. Cancer of the head and neck.In:Myers, EN; Suen, JY, editors. Cancer of the head and neck. 4th ed. Philadelphia: Saunders WB; 2003: 462-484.

Wiligen M, Kumar V. Head and neck. In: Kumar V, Abbas AK, Fausta N, editors. Robbins and Cotranpathological basis of diseases. 7th ed. Philadelphia, USA: Lippincott; 2005: 786-788.

Shetty R, Kali A. Prognostic significance of serum L-fucose level in head and neck malignancy. Int J Pharma Bio Sci. 2014;5(1):210-6.

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Published

2017-12-22

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Original Research Articles