Castleman’s disease presenting as parotid mass: a case report
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20190786Keywords:
Castleman’s disease, Parotid, Head and neck, Salivary glandAbstract
Castleman’s disease is a rare, benign, lymphoproliferative disorder of unknown etiology. It can involve any lymph node group in the body with mediastinum being the commonest site. Salivary glands are affected rarely. We report a 35 year old male patient who presented with slowly progressive, painless right sided parotid swelling for 3 years. Clinical examination showed a 4×3 cm single, firm, non-tender, non-pulsatile swelling with smooth surface and normal overlying skin present in the right parotid region. Magnetic resonance imaging (MRI) revealed a well-defined hyper-intense mass lesion on T2 measuring 3.9×3×2.8 cm and Fine needle aspiration cytology (FNAC) showed intense lymphoplasmacytic infiltrates. No conclusive diagnosis could be made on the basis of FNAC. So, the excision of parotid mass with facial nerve preservation was done. The final histopathology confirmed the diagnosis as Castleman’s disease. Although Castleman’s disease in the parotid gland is rare, clinicians should consider it as the differential diagnosis of any solid tumors that exhibit non-specific presenting characteristics and surgical excision is preferred treatment for unicentric disease.
References
Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956;9(4):822-30.
Gurbuzler L, Ceylan A, Yilmaz M, Vural C. Castleman's disease of the parotid gland: a case report. Kaohsiung J Med Sci. 2010;26(8):444-7.
Erdogan F, Altas S, Altas E, Yoruk O, Ozmen SA. A rare location of Castleman's disease: parotid region. N Z Med J. 2008;121(1278):86-90.
Goodisson DW, Carr RJ, Stirling RW. Parotid presentation of Castleman's disease: report of a case. J Oral Maxillofac Surg. 1997;55(5):515-7.
Reece B, Ord R, Papadimitriou J. Rare presentation of unicentric Castleman's disease in the parotid gland. J Oral Maxillofac Surg. 2012;70(9):2114-7.
Sherman JA, Birtwhistle CJ, Davies HT. A rapidly expanding lesion in the neck: unusual presentation of Castleman's disease. Int J Oral Maxillofac Surg. 2001;30(5):458-60.
Temirbekov D, Yazici ZM, Ergelen R, Turgut H, Kayhan FT. Castelman disease of the parotid gland: an unusual entity. Otolaryngol Pol. 2014;68(4):208-11.
Iaconetta G, Friscia M, Dell'Aversana Orabona G, de Biasi S, Romano A, Piombino P, et al. Castleman's disease mimicking a parotid gland tumor: report of a case and review of the literature. Eur Rev Med Pharmacol Sci. 2014;18(8):1241-6.
Jiang L, Zhao LY, Liu Y, Zhao YF. Castleman’s diseaseof the neck: report of 4 cases with unusual presentations. J Oral Maxillofac Surg. 2011;69(4):1094-9.
Tan TY, Pang KP, Goh HK, Teo EL, Abhilash B, Walford N. Castleman's disease of the neck: a description of four cases on contrast-enhanced CT. Br J Radiol. 2004;77(915):253-6.