Mismatch negativity in children with cochlear implant

Authors

  • Mai Hamid Audiovestibular Medicine, Ministry of Health, Egypt
  • Mona Ahmed Kotait Audiovestibular Medicine, Tanta University, Egypt
  • Enaas Ahmad Kolkaila Audiovestibular Medicine, Tanta University, Egypt

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20193856

Keywords:

Cochlear implants, Mismatch negativity, Auditory discrimination

Abstract

Background: Cochlear implant provides a great opportunity for children with severe to profound sensorineural hearing loss to restore normal hearing. Identifying mismatch negativity (MMN) in cochlear implant recipients helps to assess the role of central auditory structures in processing speech stimuli in those patients. The objective of the present study is to evaluate tone and speech discrimination in cochlear implanted children using mismatch negativity test.

Methods: MMN was recorded in 35 children. They were divided into two groups. Control group consisted of 15 normal hearing children, their age ranged from 3-11 years. Study group consisted of 20 children fitted with unilateral CI, and their age matched the control group. Two oddball paradigms were used; the first was tone bursts (1000 Hz as standard stimulus and 1050 Hz as deviant stimulus). The second was synthesized speech stimuli (/da/ as standard stimulus and /ga/ as deviant one). Both paradigms were presented at 75dB SPL.

Results: All cochlear implanted children included showed MMN on using both oddball paradigms. Comparing results of both groups revealed statistically significant differences in MMN latency and amplitude. There was a significant positive correlation between MMN latencies and the implantation age as well as the duration of hearing loss before implantation.

Conclusions: MMN provides an objective tool to assess the auditory discrimination abilities in cochlear implanted children which may help in their rehabilitation and also in the optimum setting of their devices.

References

Spencer PE, Marschark M. Evidence-based practice in educating deaf and hard-of-hearing students. Oxford University Press; 2010.

Cruz I, Quittner AL, Marker C, DesJardin JL. Identification of effective strategies to promote language in deaf children with cochlear implants. Child development. 2013;84(2):543-59.

Silva LAF, Couto MIV, Magliaro FC, Tsuji RK, Bento RF, de Carvalho ACM, et al. Cortical maturation in children with cochlear implants: Correlation between electrophysiological and behavioral measurement. PloS ONE. 2017;12(2):171-7.

Zeng F G, Tang Q, Lu T. Abnormal pitch perception produced by cochlear implant stimulation. PLoS ONE. 2014;9:e88662.

Holden LK, Finley CC, Firszt JB, Holden TA, Brenner C, Potts L G, et al. Factors affecting open-set word recognition in adults with cochlear implants. Ear and hearing. 2013;34(3):342.

Kelly AS, Purdy SC, Thorne PR. Electrophysiological and speech perception measures of auditory processing in experienced adult cochlear implant users. Clin Neurophysiol. 2005;116:1235-46.

Roman S, Canevet G, Marquis P, Triglia JM, Liegeois-Chauvel C. Relationship between auditory perception skills and mismatch negativity recorded in free field in cochlear-implant users. Hear Res. 2005;201:10-20.

Naatanen R, Escera C. Mismatch negativity: clinical and other applications. Audiol Neurotol. 2000;5(3-4):105-10.

Gabr TA. Mismatch negativity (MMN): indexing auditory discrimination in cochlear implants. Hear Balan Commun. 2018;16(1):21-8.

Hahne A, Mainka A, Leuner A, Mürbe D. Adult cochlear implant users are able to discriminate basic tonal features in musical patterns: Evidence from event-related potentials. Otol Neurotol. 2016;37(9):360-8.

Obuchi C, Harashima T, Shiroma M. Auditory evoked potentials under active and passive hearing conditions in adult cochlear implant users. Clin Exp Otorhinolaryngol. 2012;5:6-9.

Torppa R, Salo E, Makkonen T, Loimo H, Pykalainen J, Lipsanen J, et al. Cortical processing of musical sounds in children with Cochlear Implants. Clin Neurophysiol. 2012;123(10):1966-79.

Zhang F, Benson C, Fu QJ. Cortical encoding of pitch contour changes in cochlear implant users: a mismatch negativity study. Audiol Neurotol. 2013;18(5):275-88.

Kraus N, Micco AG, Koch DB, McGee T, Carrell T, Sharma A, et al. The mismatch negativity cortical evoked potential elicited by speech in cochlear-implant users. Hear Res. 1993;65(1-2):118-24.

Elkayal VSA, Mourad MI, Elbanna MM, Talaat MAM. Evaluation of factors that influence cochlear implant performance. Advan Arab Acad Audio-Vestibul J. 2016;3:1-8.

Rahman TTA, Nada IM, Kader HAA, Monem AAA. Neural representation of speech in pediatric cochlear implant recipients. Egypt J Otolaryngol. 2017;33(2):535.

Kileny PR, Boerst A, Zowlan T. Cognitive evoked potentials to speech and tonal stimuli in children with implants. Otolaryngol Head Neck Surg. 1997;117:161-9.

Gifford RH. Cochlear implant candidacy in children: audiological considerations. In pediatric cochlear implantation. New York, NY: Springer; 2016: 27-41.

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Published

2019-08-27

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Section

Original Research Articles