A clinical study of complications of diphtheria

Pooja Arya, Manphool S. Maharia, Ramesh K. Kadela, Deepchand .


Background: Diphtheria is an acute infectious preventable disease of childhood caused by C. diphtheriae. Diphtheria is a localized infection of mucous membrane or skin.

Methods: The present study was carried out in the Department of Otorhinolaryngology S.P. Medical College and associated group of hospital. In this study all cases of diphtheria and all age groups which attended ENT OPD and emergency department during period from 1/1/2010 to 31/12/2010 were included.  

Results: In the present study highest numbers of cases were recorded among 5-10 years of age followed by 0-5 year of age group. 57.59% patients were male and 42.41% patients were female. It was found that occurrence of diphtheria was highest in month November and October and was quit frequent during September and December. No cases during April, June and July. It was observed that most common post diphtheria complication was myocarditis (23.42%) followed by neurological complication.

Conclusions: In order to prevent complication of the disease active immunization is customary and in order to detect the disease at early stage and for prompt treatment masses should be educated regarding the dreadful nature of the disease.


Diphtheria, Outcomes, Cardiac involvement, Neurological involvement

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John TJ. Resurgence of diphtheria in india in 21st century. Indian J Med Res. 2008;128;669-70.

Maheriya KM, Pathak GH, Anuya VC. Clinical and epidemiological profile of diphtheria in tertiary care hospital. Gujarat Med J. 2014;69(2):105-9.

International Institute for Population Sciences (IIPS) and Macro International. National Family Health Survey (NFHS-4). 2015–16.

Jain A, Samdani S, Meena V, Sharma MP. Diphtheria: it is still prevalent. Int J Pediatr Otorhinolaryngol. 2016;86:68–71.

Jayashree M, Shruthi N, Singhi S. Predictors of outcome in patients with diphtheria receiving intensive care. Indian Pediatr. 2006;43:155-60.

Lumio JT, Groundstroem KW, Melnick OB, Huhtala H, Rakhmanova AG. Electrocardiographic abnormalities in patients with diphtheria: a prospective study. Am J Med. 2004;116:78-83.

Galazka A. The changing epidemiology of diphtheria in the vaccine era. J Infect Dis. 2000;181:2-9.

Rob Roy Macgregor (ed). Corynebacterium diphtheria. In: Bennett JE, Dolin R, Blaser MJ. Mande H, Douglas and Bennett's principles and practice of infectious diseases. 6th edition. Chapter 137. Philadelphia: Elsevier; 2005: 290-291.

Manikyamba D, Satyavani A, Deepa P. Diphtheritic polyneuropathy in the wake of resurgence of diphtheria. J Pediatr Neurosci. 2015;10:331–4.

Mateen FJ, Bahl S, Khera A, Sutter RW. Detection of diphtheritic polyneuropathy by acute flaccid paralysis surveillance, India. Emerg Infect Dis. 2013;19:1368–73.

Logina I, Donaghy M. Diphtheritic polyneuropathy: a clinical study and comparison with Guillain-Barre syndrome. J Neurol Neurosurg Psychiatry. 1999;67:433–8.

Piradov MA, Pirogov VN, Popova LM, Avdunina IA. Diphtheritic polyneuropathy: clinical analysis of severe forms. Arch Neurol. 2001;58:1438–42.