The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

Authors

  • Himanshu Chhagan Bayad Department of ENT, Government Medical College, Patiala, Punjab, India
  • Sanjeev Bhagat Department of ENT, Government Medical College, Patiala, Punjab, India
  • Dimple Sahni Department of ENT, Government Medical College, Patiala, Punjab, India
  • Navneet Kaur Department of ENT, Government Medical College, Patiala, Punjab, India
  • Ravinder Singh Department of ENT, Government Medical College, Patiala, Punjab, India
  • Dinesh Kumar Sharma Department of ENT, Government Medical College, Patiala, Punjab, India
  • Baldev Singh Department of ENT, Government Medical College, Patiala, Punjab, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20194931

Keywords:

Toluidine blue, Leukoplakia, Erythroplakia, Squamous cell carcinoma, Early detection, Adjunctive tool

Abstract

Background: Oral carcinoma is among the most prevalent malignancies of head and neck region and is often diagnosed in the advanced stage with significant morbidity and treatment cost. Thus, there is a need for early detection of oral premalignant and malignant lesions. Toluidine blue staining can be used for early detection of these lesions.

Methods: The study included 50 patients with clinically suspicious oral premalignant and malignant lesions. These lesions were subjected to toluidine blue staining and biopsy. Diagnoses were confirmed by histopathological examination.  

Results: Sensitivity and specificity of toluidine blue for oral premalignant lesions was 92.30% and 80% respectively with the positive predictive value of 92.30%, negative predictive value of 80% and accuracy of 88.88%. Sensitivity and specificity of toluidine blue for oral malignant lesions was 96.30% and 80% respectively with the positive predictive value of 96.30%, negative predictive value of 80% and accuracy of 93.75%.

Conclusions: The simplicity of toluidine blue staining and its accuracy suggest that it can be a useful adjunctive tool to diagnosis of oral lesions. Results should be carefully evaluated and correlated with clinical findings and histopathological diagnosis.

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Published

2019-10-23

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Original Research Articles