T4 squamous cell cancer of buccal mucosa successfully treated combination of interstitial brachytherapy, concurrent chemo-radiotherapy and salvage surgery

Authors

  • Jyoti Sharma Department of Radiation Therapy and Oncology, IGMC Shimla, Himachal Pradesh, India http://orcid.org/0000-0003-1517-3214
  • Aman Sharma Department of Radiation Therapy and Oncology, IGMC Shimla, Himachal Pradesh, India
  • Swati Verma Department of Radiation Therapy and Oncology, IGMC Shimla, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20205642

Keywords:

Buccal mucosa, Interstitial brachytherapy implant, CRT

Abstract

We report a case of advanced case of right sided buccal mucosa deemed inoperable achieving long term cure with a combination of interstitial brachytherapy and concurrent chemoradiotherapy (CRT) followed by salvage surgery for small recurrence. The patients were considered for upfront double plane 12 catheter implant to a dose of 25 Gy in 8 fractions at the rate of 3.125 Gy per fraction. Two fractions were delivered in a day at least 6 hours apart. Thereafter patient was subjected to CRT to a dose of 40 Gy in 20 fractions. At follow up there was complete resolution of disease barring a small induration raw area at angle of mouth, which was successfully managed by salvage surgery. Patient is now on regular follow up for 18 months from completion of treatment and is disease free for 1 year.

Author Biography

Jyoti Sharma, Department of Radiation Therapy and Oncology, IGMC Shimla, Himachal Pradesh, India

Medical Officer Specialist Department of Radiation therapy and oncology

References

Mathur P, Sathishkumar K. Report From National Cancer Registry Programme, India (National Centre for Disease Informatics and Research, Bengaluru, India). Cancer Statistics, 2020.

Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med. 1995;24(10):450-3.

grawal M, Pandey S, Jain S, Maitin S. Oral cancer awareness of the general public in Gorakhpur city, India. Asian Pac J Cancer Prev. 2012;13:5195-9.

Prisciandaro JI, Foote RL, Herman MG, Lee SJ, LaJoie WN, Van Blarcom AB et al. A buccal mucosa carcinoma treated with high dose rate brachytherapy. Journal of Applied Clinical Medical Physics. 2005;6:8-12.

Chen AY, Frankowski R, Bishop-Leone J, Hebert T, Leyk S, Lewin J et al. The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. D. Anderson dysphagia inventory. Arch Otolaryngol Head Neck Surg. 2001;127(7):870-6.

Puthawala A, Nisar Syed AM, Gamie S, Chen YJ, Londrc A, Nixon V. Interstitial low-dose-rate brachytherapy as a salvage treatment for recurrent head-and-neck cancers: long-term results. Int J Radiat Oncol Biol Phys. 2001;51(2):354-62

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Published

2020-12-24

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Section

Case Reports