DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20211590

Small cell neuroendocrine carcinoma of subglottis: a case report

Sunil K. C., B. Y. Praveen Kumar, Malavika Hari, Mir Arshad Ali, M. K. Veenapani

Abstract


Small cell carcinoma is an uncommon type of malignant epithelial neuroendocrine neoplasm. It is most commonly of pulmonary origin and only less than five percent of all tumours are extrapulmonary. Esophagus, stomach, colon and rectum, gall bladder, head and neck, urinary bladder, prostate, skin and cervix are the most common extrapulmonary sites. Small cell carcinoma of larynx accounts for less than one percent of all laryngeal neoplasms. It is a highly aggressive neoplasm with poor prognosis. It most commonly affects supraglottis in males who are heavy smokers in their sixth and seventh decades. Various paraneoplastic syndromes can also be associated with the neoplasm. More than 90% of small cell laryngeal neoplasms present with metastatic disease. Surgery is not considered the initial treatment of choice; concurrent chemo radiotherapy is proven to provide longer survival. We report the rare case of extrapulmonary small cell neuroendocrine tumour in subglottis in a non-smoker female patient.


Keywords


Small cell neuroendocrine carcinoma, Laryngeal neoplasms, Extrapulmonary, Subglottis

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References


Mikic A, Zvrko E, Trivic A, Stefanovic D, Golubovic M. Small cell neuroendocrine tumour of the larynx-a small case series. Coll Antropol. 2012;36(2):201-4.

Batsakis JG, el-Naggar AK, Luna MA. Neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol. 1992;101(8):710-4.

Barbeaux A, Duck L, Weynand B, Desuter G, Hamoir M, Gregoire V, et al. Primary combined squamous and small cell carcinoma of the larynx: Report of two cases and discussion of treatment modalities. Eur Arch Oto-Rhin-Laryngol. 2006;263:786-90.

Ferlito A, Rinaldo A. Small cell neuroendocrine carcinoma of the larynx: a preventable and frustrating disease with a highly aggressive lethal behavior. J Otorhinolaryngol Relat Spec. 2003;65:131-3.

Kim HJ, Hwang EG. Small cell carcinoma of the larynx: imaging findings. Auris Nasus Larynx. 1997;24:423-7.

Olofsson J, van Nostrand AWP. Anaplastic small cell carcinoma of the larynx: Case report. Ann Otol Rhinol Laryngol. 1972;81:284-7.

Ferlito A, Rinaldo A. Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review. Head Neck. 2008;30:518-24.

Gnepp DR. Small cell neuroendocrine carcinoma of the larynx: A critical review of the literature. J Otorhinolaryngol Relat Spec. 1991;53:210-9.

Gripp FM, Risse EKJ, Leverstein H, Snow GB, Meijer CJLM. Neuroendocrine neoplasms of the larynx. Importance of the correct diagnosis and differences between atypical carcinoid tumors and small cell neuroendocrine carcinoma. Eur Arc Otorhinolaryngol. 1995;252:280-6.

Trotoux J, Glickmanas M, Sterkers O, Trousset M, Pinel J. Schwartz-Bartter syndrome: presentation of a subglottal small cell laryngeal carcinoma. Ann Otolaryngol Chir Cervicofac. 1979;96(6):349-58.

Medina JE, Moran M, Goepfert H. Oat cell carcinoma of the larynx and Eaton-Lambert syndrome. Arch Otolaryngol. 1984;110:123-6.

Bishop JW, Osamura RY, Tsutsumi Y. Multiple hormone production in an oat cell carcinoma of the larynx. Acta Pathol Jpn. 1985;35(4):915-23.

Baugh RF, Wolf GT, Beals T, Krause CJ, Forastiere A. Small cell carcinoma of the larynx: Results of the therapy. Laryngoscope. 1986;96:1283-90.

Baugh RF, Wolf GT, McClatchey KD. Small cell carcinoma of the head and neck. Head Neck Surg. 1986;8:343-54.

Gnepp DR, Ferlito A, Hymas V. primary anaplastic small cell (oat cell) carcinoma of the larynx: review of the literature and report of 18 cases. Cancer. 1983;51:1731-45.

Soga J, Ferlito A, Rinaldo A. endocarcinomas (carcinoids and their variants) of the larynx: a comparative consideration with those of other sites. Oral Oncol. 2004;40:668-72.

Ferlito A, Pesavento G, Recher G. Long term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. Auris Nasus Larynx. 1986;13:113-23.