DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20214678

Comparative study of brainstem evoked response audiometry in diabetic patients and non-diabetic subjects to assess the involvement of central auditory pathway

Shanthimalar R., Muthuchitra S., Mary Nirmala S., Udhaya Chandrika G., Mohamed Rasith H.

Abstract


Background: Diabetes mellitus (DM) which is prevalent in world is associated with sensorineural hearing loss. Brainstem evoked response audiometry (BERA) is a simple, non-invasive procedure to detect early impairment of acoustic nerve and auditory pathway. The present study is under taken to evaluate the impact of DM on BERA parameters. Aim of the study was to compare the BERA of diabetic patients to those of age and gender matched controls to assess the involvement of central auditory pathway.

Methods: A cross sectional study was conducted on 35 diabetic patients, aged 35 to 55 years, who were on treatment for at least 2 years, and 35 age and sex matched control participants, were subjected for BERA at 70,80 and 90 dB. The waveforms, absolute latency of wave I, wave III, wave V and interwave/ inter peak latency of I-III, III-V and I-V were analyzed with respect to both groups.

Results: The absolute latency of wave III and wave V, interpeak/ interwave latency of I-III, interpeak/ interwave latency of I-V, III-V and absolute latency of wave V were highly significant at corresponding tested stimuli in the diabetic group compared to the control group.

Conclusions: Early involvement of central auditory pathway in diabetic patients, can be detected with fair accuracy with auditory evoked potential studies; if done on a regular basis warrants meticulous glycemic control and prevents further damage.


Keywords


BERA, DM, Absolute latency, Interwave/ inter peak latency

Full Text:

PDF

References


Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, Isselbacher KL. Harrison's Principles of Internal Medicine. 2005;6.

Donald MW, Bird CE, Lawson JS, Letemendia FJJ, Monga TN, Urridge DHC et al. Delayed auditory brainstem responses in diabetes mellitus J Neurol Neurosurg Psychiatry. 1981;44(7):641-4.

Fedele D, Martini A, Cardone C, Comacchio F, Bellavere F, Molinari G et al. Impaired auditory brainstem-evoked responses in insulin-dependent diabetic subjects. Diabetes. 1984;33;1085-9.

Khardori R, Soler NG, Good DC, Devlesc Howard AB, Broughton D, Walbert J. Brainstem auditory and visual evoked potentials in type 1 (insulin- dependent) diabetic patients. Diabetologia. 1986;29(6):362-5.

Virtanierni J, Laakso M, Nuutinen J, Karjalainens. Quoted by Booth JB. Scott Brown’s otolaryngology. 6th ed, Butterworths, London. 1997;3:95.

Durmus C, Yetiser S, Durmus O. Auditory brainstem evoked responses in insulin-dependent (ID) and non-insulin-dependent (NID) diabetic subjects with normal hearing. Int j audiol. 2004;43(1):29-33.

Kurien M, Thomas K, Bhanu TS. Hearing threshold in patients with diabetes mellitus. J Laryngol Otol. 1989;103;164-8.

King H, Aubert RE, Herman WH: Global burden of diabetes, 1995-2025: prevalence numerical estimates, and projections. Diabetes care. 1998;21(9):1414-31.

Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients - a cross-sectional hospital-based survey in urban China. Health Quality Life Outcomes. 2010;8:62.

Maia CAS, Campos CAH. Diabetes Mellitus as etiological factor of hearing loss. Braz J Otorhinolaryngol. 2005;71(2):208-14.

Di Leo MA, Di Nardo W, Cercone S, Ciervo A, Lo Monaco M, Greco AV et al. Cochlear dysfunction in IDDM patients with subclinical peripheral neuropathy. Diabetes Care. 1997;20(5):824-8.

Marchiori LMM, Gibrin PCD. Diabetes mellitus: prevalência de alterações auditivas. Arq Bras Endocrinol Metab. 2003;47(1):82-6.

Ferreira Jr. CA, Guimarães RES, Becker HMG, Silva CDL, Gonçalves TML, Crosara PFTB et al. Avaliação metabólica do paciente com labirintopatia. Arq Otorrinolaringol. 2000;4(1):28-32.

Dall’Igna C, Batista LRP, Siqueira MK. Patogênese da disacusia neurossensorial em Diabetes Mellitus. Rev Bras Otorrinolaringol. 2000;66(2):155-8.

Bittar RMB, Sanchez TG, Santoro PP, Medeiros IRT. O metabolism daglicose e o ouvido interno. Arq Fund Otorrinolaringológica. 1998;2(1):4-7.

Wright A. Anatomy and Ultrastructure of human ear”, in Scott-Brown’s Otolaryngology, 6th edition. 1997;1(1):1-49.

Niparko JK, Richardson MA. Cummings Otolaryngology Head and Neck Surgery, edition 5, Mosby Elsiever, USA. 2010;3(7 and 8):1821-2956.

Watkinson JC, Clarke RW. Scott Brown’s Otorhinolaryngology, Head and Neck Surgery, edition - 8, CRC PRESS, UK. 2018;2(46-53):56-73.

Dhingra PL, Dhingra S. Diseases of Ear, Nose and Throat, 6th Edition, ch. 1 and 2. Elsiever, India. 2014;1.

Hayes SH, Ding D, Salvi RJ, Allman BL. Anatomy and physiology of the external, middle and inner ear. Handbook of Clinical Neurophysiology: New York: Elsevier. 2013;3-23.

Rattay F, Danner SM. Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: evidence from computer modeling. Hearing research. 2014;315:67-79.

Akinpelu OV, Ibrahim F, Waissbluth S, Daniel SJ. Histopathologic changes in the cochlea associated with diabetes mellitus-a review. Otol Neurotol. 2014;35(5):764-74.

Virtanierni J, Laakso M, Nuutinen J, Karjalainens. Quoted by Booth JB. Scott. Brown’s otolaryngology. 6th ed. Butterworths, London. 1997;3:95.

Scott Brown’s Otorhinolaryngology, Head and Neck Surgery, Chapters 226, edition 7th CRC PRESS, UK. 2008;3.

Brugge JF. Anatomy and physiology of auditory pathways and cortex. Handbook Clin Neurophysiol. 2013;10:25-59.

Hackney CM. Anatomical features of the auditory pathway from cochlea to cortex. Brit med bull. 1987;43(4):780-801.

Møller AR, Jannetta PJ. Compound action potentials recorded intracranially from the auditory nerve in man. Experimental neurol. 1981;74(3):862-74.

Celesia GG. Disorders of Peripheral and Central Auditory Processing1: Disorders of Peripheral and Central Auditory Processing. Elsevier Health Sci. 2013.

Friedman SA, Schulman RH, Weiss S. Hearing and Diabetic neuropathy. Arch Intern Med. 1975;135:573-6.

Konrad-Martin D, Reavis KM, Austin D, Reed N, Gordon J, McDermott D, Dille MF. Hearing impairment in relation to severity of diabetes in a veteran cohort. Ear and hearing. 2015;36(4):381.

Ren J, Ma F, Zhou Y, Xu A, Zhang J, Ma R et al. Hearing impairment in type 2 diabetics and patients with early diabetic nephropathy. J diabetes its complications. 2018;32(6):575-9.