Published: 2022-01-25

A clinical study and management of ulceromembranous lesions of oral cavity

Stanley John, Muniraju M., Sreekala S. S., Julie P. R.


Background: This study was done at Dr BR Ambedkar Medical College, Bangalore between November 2019 to May 2021 in the department of ENT to know the clinical profile of patients presenting with ulceromembranous lesions in oral cavity.

Methods: A longitudinal prospective study done with the patients coming to Department of Otorhinolaryngology and also the patient referred from other departments of Dr. B R. Ambedkar medical college from November 2019 to May 2021.After obtaining informed written consent, all patients with ulceromembranous lesions in the oral cavity, a detailed medical history recorded, thorough ENT clinical assessment as well as a systemic check up done. Swab was obtained and sent for Gram's stain, culture, and sensitivity, KOH mount. In suspected malignant ulceroproliferative lesions, biopsies were collected from the edges of the lesions. All information was entered into a custom-made case preforma. Patients were treated symptomatically with appropriate antibacterials and antifungal medicines. Patients with malignant ulcers who gave consent were taken for surgery.

Results: There were 100 cases of ulceromembranous lesions in oral cavity. Females (60%) were most commonly affected. Majority of patients had tobacco chewing as a risk factor for the development of malignant lesions.15% of study subjects had aphthous ulcer as the most common cause of ulceromembranous lesion. Malignant lesions constitute 27% of total cases.

Conclusions: Malignant etiology is most commonly associated with ulceromembranous lesions in oral cavity in our study.


Ulceromembranouslesions, Oral cavity, Carcinoma tongue, Smoking, Hard palate, Tobacco

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Garber A, Klein E, Bruce S, Sankoh S, Mohideen P. Metformin-glibenclamide versus metformin plus rosiglitazone in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Diabetes Obes Metab. 2006;8(2):156-63.

O'Brien C. Drug addiction and drug abuse. In: Brunton LB, Lazo JS, Parker KL, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill. 2005;607-29.

National Cancer Institute. Fact sheet: targeted cancer therapies, 2012. Available at: Accessed on 9 June 2014.

Saintrain MV, Holanda TG, Bezerra TM, de Almeida PC. Prevalence of soft tissue oral lesion in elderly and its relations with deleterious habits. Gerodontology. 2012;29(2):130-4.

Phelan JA, Eisig S, Freedman PD. Major aphthous like ulcers in patients with AIDS. Oral Surg Oral Med Oral Pathol. 1991;71(1):68-72.

Mahawar P, Anand S, Sinha U. Screening for pre-malignant conditions in the oral cavity of chronic tobacco chewers. National Journal of Community Medicine. 2011;2(1):82-5.

Mortazavi H, Safi Y, Baharvand M, and Rahmani S. Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. International Journal of Dentistry. 2016;7278925.

Santosh P, Nidhi Y, Prashant P, Sumita K. Prevalence and the relationship of oral mucosal lesions in tobacco users and denture wearers in the North Indian population. J Family Community Med. 2013;20(3):187-91.

Sridhar RD, Shoban BA. Study of Ulcero-membranous Lesions of Tonsil in an Indian scenario. Indian J Otolaryngol Head Neck Surg. 2017;69(1):16-9.

Thimmappa TD. A study on the clinical profile of ulcers and membranous lesions of oral cavity and oropharynx. Int J Res Med Sci. 2014;2(1):180-5.

Isaac U, Issac JS, Khoso NA. Histopathologic features of oral submucous fibrosis: a study of 35 biopsy specimens. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):556-60.

Zakrzewska JM, Robinson P, Williams IG. Severe oral ulceration in patients with HIV infection: a case series. Oral Dis. 1997;3(1):S194-6.

Sujatha RS, Rakesh N, Deepa J, Ashish L, Shridevi B. Rhino cerebral mucormycosis. A report of two cases and review of literature. J Clin Exp Dent. 2011;3:256-60.

Aggarwal P, Saxena S, Bansal V. Mucormycosis of maxillary sinus. J Oral Maxillofac Pathol. 2007;11:66-9.

Mehta FS, Pindborg PP, Gupta PC. Epidemiologic and histologic study of oral cancer and leukoplakia among 50,915 villagers in India. J American Cancer Society. 1969;24(4):832-49.